Translational Physiology TRANSLATIONAL PHYSIOLOGY Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma
نویسندگان
چکیده
A. Agrawal, S. Rengarajan, K. B. Adler, A. Ram, B. Ghosh, M. Fahim, and B. F. Dickey Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Physiology, Vallabhbhai Patel Chest Institute, Delhi, India; Molecular Immunogenetics Laboratory, Institute of Genomic and Integrative Biology, Delhi, India; Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, North Carolina; and Department of Pulmonary Medicine, MD Anderson Cancer Center, Houston, Texas
منابع مشابه
Inhibition of mucin secretion with MARCKS-related peptide improves airway obstruction in a mouse model of asthma.
Allergic asthma is associated with airway epithelial cell mucous metaplasia and mucin hypersecretion, but the consequences of mucin hypersecretion on airway function are unclear. Recently, a peptide derived from the myristoylated alanine-rich C kinase substrate protein NH(2)-terminal sequence (MANS) was shown to inhibit methacholine (MCh)-induced mucin secretion from airway mucous cells by >90%...
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Rationale: Mucus hypersecretion has been shown to be an important cause of airway obstruction in COPD and asthma, and has been associated with fatal asthma. Previous in-vitro and in-vivo studies have provided direct evidence that the myristoylated alanine-rich C kinase substrate (MARCKS) is a central regulatory molecule linking secretagogue stimulation at the goblet cell surface to mucin granul...
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In a mouse model of neutrophil elastase-induced bronchitis that exhibits goblet cell metaplasia and inflammation, we investigated the effects of intratracheal instillation of the MANS peptide, a peptide identical to the NH(2) terminus of the myristoylated alanine-rich C kinase substrate (MARCKS) on mucin protein airway secretion, inflammation, and airway reactivity. To induce mucus cell metapla...
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Myristoylated alanine-rich C kinase substrate (MARCKS) protein has been recognized as a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. We recently showed that two intracellular chaperones, heat shock protein 70 (HSP70) and cysteine string protein (CSP), associate with MARCKS in the secretory mechanism. To elucidate more fully MARCKS-HSP70 in...
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Hypersecretion of mucus characterizes many inflammatory airway diseases, including asthma, chronic bronchitis, and cystic fibrosis. Excess mucus causes airway obstruction, reduces pulmonary function, and can lead to increased morbidity and mortality. MicroRNAs are small non-coding pieces of RNA which regulate other genes by binding to a complementary sequence in the target mRNA. The microRNA mi...
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